Tumour necrosis factor- up-regulates macrophage migration inhibitory factor expression in endometrial stromal cells via the nuclear transcription factor NF- B

نویسندگان

  • W. G. Cao
  • M. Morin
  • V. Sengers
  • C. Metz
  • T. Roger
  • R. Maheux
  • A. Akoum
چکیده

Unité d’endocrinologie de la reproduction, Centre de Recherche, Hôpital Saint-François d’Assise, Centre Hospitalier Universitaire de Québec, Faculté de Médecine, Université Laval, Québec, Canada, Institute for Medical Research at North Shore-LIJ, NY, USA and Service des Maladies Infectieuses, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland To whom correspondence should be addressed at: Laboratoire d’Endocrinologie de la Reproduction, Centre de Recherche, Hôpital SaintFrançois d’Assise, 10 rue de l’Espinay, Local D0-711, Québec, Québec, Canada G1L 3L5. E-mail: [email protected]

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

TRANSFORMING GROWTH FACTOR β2 UP-REGULATES GM-CSF GENE IN HUMAN BLADDER CARCINOMA CELL LINE HTB 5637

Transforming growth factor betas are multifunctional polypeptides in the cytokine superfamily. They have a growth inhibitory role on hemopoietic progenitor cells in semisolid colony assay as well as in long-term bone-marrow culture. TGF - β2 represses stromal cells, stem cell factor gene transcription, and decreases the stability of c-kit transcripts in hemopoietic cells. TGF-β also modulat...

متن کامل

O-28: Endometriosis Is Influenced by The Promoter Haplotype-Based Expression of Macrophage Migration Inhibitory Factor (MIF)

Background: Macrophage migration inhibitory factor (MIF) is a key pro-inflammatory cytokine that is secreted by accumulated active macrophages in ectopic tissue of endometriosis. MIF is involved in pathophysiological events of endometriosis, such as angiogenesis and cell proliferation. MIF that stimulates the synthesis of PGE2, leads to over-expression of local estradiol synthesis in endometrio...

متن کامل

Marked increase in macrophage migration inhibitory factor synthesis and secretion in human endometrial cells in response to human chorionic gonadotropin hormone.

Originally identified for its capacity to inhibit the random migration of macrophages in vitro, macrophage migration inhibitory factor (MIF) is now recognized as a multifunctional cytokine that modulates the immune response and acts as a growth and angiogenic factor. Recent studies showed that MIF is expressed in the human endometrium across the menstrual cycle as well as in chorionic villi fro...

متن کامل

Activation of the transcription factor NF-kappa B in human tracheobronchial epithelial cells by inflammatory stimuli.

Recent studies have shown that surface epithelial cells play a major role in the defence and inflammatory reactions of the airways. How extracellular stimuli lead to increased gene expression in these epithelial cells is not well known. In this study, we asked whether the multiunit transcription factor, nuclear factor (NF)-kappa B, which regulates the expression of genes involved in defense and...

متن کامل

Functional dichotomy of A20 in apoptotic and necrotic cell death.

ROS (reactive oxygen species) play important roles in the progression of a number of human pathologies. ROS promote cell death, but can also induce gene transcription. The transcription factor NF-kappaB (nuclear factor kappaB) plays a critical role in oxidative stress responses. One of the proteins regulated by NF-kappaB is the zinc-finger protein A20. In TNF (tumour necrosis factor)-alpha sign...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2005